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Dangers of taking metformin

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    Dangers of taking metformin


    As many know, metformin is the number one prescription medication for type-2 diabetes. The patent for the name-brand of this patent medicine, Glucophage®, expired years ago and as a result generic-brand competition (metformin) brought this patent medicine’s price down so that it’s relatively inexpensive, especially when compared with nearly any other medication still covered by a patent. Mainstream medical research has found other uses for this un-natural molecule, including (but not limited to) lipid, blood pressure, and insulin resistance lowering effects, anti-cancer effects, improvement of polycystic ovarian syndrome, combatting Alzheimer’s disease, and extending life span in mice. Some proponents of natural therapies – including, surprisingly, two nationally and internationally circulated health magazines – have climbed on the metformin bandwagon, writing articles about the “health benefits” of metformin, and even advocating that otherwise healthy people take this patent medicine every day as a preventive. They admit that there are known side effects, but write that these are few, and that the benefits outweigh the risks. If there aren’t any natural treatment alternatives that are as effective, or more effective, than a patent medicine or other un-natural molecule – especially in serious or life-threatening situations – then the use of a patent medication of course makes sense. But when there , the rule is – and always should be – to “Copy Nature.” Human bodies are formed from the molecules of planet Earth, and powered by the energies of this planet. sertraline 500mg tablets Unfortunately, metformin also has one of the lowest “patient adherence” rates, because of its side effects which can appear within hours of taking your first dose. While there are actually many positive qualities about this drug compared to other diabetes medications, metformin side effects can be remarkably uncomfortable, disrupting your daily life. It works by reducing the amount of sugar your liver releases throughout the day, and it increases your body’s sensitivity to insulin. It can also reduce the amount of glucose that is absorbed from the food you eat, which in turn reduces your blood sugar levels after eating. directly cause hypoglycemia; however when paired with other diabetes medications that do lower blood sugar, metformin could result in low blood sugar until those other medication doses are reduced to compensate. While it was designed for people with type 2 diabetes, people with type 1 diabetes struggling with severe insulin resistance can take it for, too. However, when used by patients taking it “off-label” for type 1 diabetes, it could lead to hypoglycemia because it would decrease your needs for insulin via injection or pump.

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    This is an incredibly sad state of affairs since the treatment is widely available and incredibly safe over-the-counter Vitamin B12 Supplements and these could be easily prescibed to every patient taking metformin if doctors were simply more aware of this serious problem with potentially devastating consequences. viagra woman Along with its needed effects, metformin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking metformin More Common. Abdominal or stomach discomfort; cough or hoarseness The metformin “belly bomb” hits in 20 to 30% of cases. Digestive disturbances are the most commonly reported side effects of metformin, affecting 20- 30% of those taking it. These side effects can be dose-related and reducing the dose often reduces symptoms.

    Before starting treatment, it is important to be aware of any potential metformin dangers. The medication may cause a life-threatening condition called lactic acidosis, and the risk of this problem increases with certain medical conditions. Therefore, you should tell your healthcare provider about all other existing medical conditions you have before starting metformin. There are also a number of side effects that may occur with metformin. Some of the most commonly reported side effects include abdominal discomfort, diarrhea, indigestion, and nausea or vomiting. While most side effects are mild, some are potentially serious and require immediate medical attention, including chest pain, symptoms of high blood sugar (such as blurred vision or shortness of breath), or symptoms of low blood pressure (such as cold sweats or extreme hunger). This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Perhaps your doctor has told you about it, has recently started you on it or has been prescribing it to you for years to keep your blood sugar under control. Metformin has been available by prescription in the US for more than 20 years and in Europe for more than 40 years. US doctors write nearly 60 million prescriptions a year. It’s recommended as the go-to-first prescription for people with diabetes by the American Diabetes Association, the American Association of Clinical Endocrinologists and the American College of Physicians. We know broadly but still not exactly, how it works. Even more surprising, new health benefits—and side effects—keep popping up. In fact, we’ve only recently learned that metformin might protect the heart, fight cancer and even boost longevity. On the other hand, it can, rarely, lead to a potentially fatal side effect, and it can even make a common diabetes complication —the bloom of the French lilac, also known as goat’s rue and Italian fitch—for patients with what we now recognize as diabetes. In the 1950s, medical researchers identified a compound in the lilac, metformin, that appeared to reliably and safely reduce high blood sugar.

    Dangers of taking metformin

    The Dangers Of Metformin - Ben Greenfield Fitness, Metformin Side Effects in Detail -

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  4. How to use Metformin HCL. Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. If you have any questions.

    • Metformin Oral Uses, Side Effects, Interactions, Pictures. - WebMD
    • Avoid the Metformin Bandwagon Foundation for Alternative.
    • Metformin Oral Route Precautions - Mayo Clinic

    Metformin causes some common side effects. These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a. buy kamagra sukhumvit This metformin side effect occurs in fewer than 10 out of every 100,000 patients—0.005%—but it’s fatal half the time it occurs. That’s why your doctor should test you regularly for kidney function if you’re taking metformin. While at first glance it seems that Side Effects of Metformin are rare, a closer look and a little math show that there are some serious problems that can occur when taking this drug, and others that can and should be prevented easily, but are usually not due to a medical community that simply does not use nutritional supplements in the.

     
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    Indicated to reduce the incidence of breast cancer in women at high risk for breast cancer; high risk is defined as women aged ≥35 years with a 5-year predicted risk of breast cancer ≥1.67% (calculated by the Gail Model) 20 mg PO q Day for 5 years Data are limited for use Hypersensitivity Pregnancy Undiagnosed vaginal bleeding Patients who require concomitant warfarin therapy or have a history of deep vein thrombosis or pulmonary embolus if indication for treatment is either reduction of breast cancer incidence in high-risk patients or risk reduction of invasive breast cancer after treatment of DCIS Liver cancer and changes in liver enzyme levels reported with use; on rare occasions, a spectrum of more severe liver abnormalities including fatty liver, cholestasis, hepatitis and hepatic necrosis, that have included fatalities, also reported; monitor liver function periodically Unknown whether an increased risk for other (non-uterine) cancers is associated with tamoxifen Hypercalcemia reported in some breast cancer patients with bone metastases within a few weeks of starting treatment; if hypercalcemia occurs, treat as appropriate; if hypercalcemia is severe, discontinue therapy CYP2D6 polymorphism-CYP2D6 converts tamoxifen to active metabolite endoxifen; lowered CYP2D6 activity or concomitant CYP2D6 inhibitors may reduce tamoxifen efficacy Decreases in platelet counts, usually to 50,000-100,000/mm3, infrequently lower, reported in patients receiving therapy for breast cancer; hemorrhagic episodes have occurred, but not certain if episodes were due to tamoxifen therapy; leukopenia, sometimes in association with anemia and/or thrombocytopenia reported; neutropenia and pancytopenia also reported; perform periodic complete blood counts, including platelet counts Ocular disturbances, including corneal changes, decrement in color vision perception, retinal vein thrombosis, and retinopathy reported; an increased incidence of cataracts and need for cataract surgery reported; patients should seek medical attention if they experience visual disturbance There is increased incidence of thromboembolic events, including deep vein thrombosis and pulmonary embolism, during tamoxifen therapy; when tamoxifen is coadministered with chemotherapy, there is further increase in risk of thromboembolic events; for treatment of breast cancer, carefully consider risks and benefits of tamoxifen in women with a history of thromboembolic events; advise patients to seek medical attention immediately if signs or symptoms of a thromboembolic event occur Increased incidence of uterine malignancies (endometrial adenocarcinoma and uterine sarcoma), including fatal cases, reported with treatment; underlying mechanism unknown, most uterine malignancies seen with tamoxifen are classified as adenocarcinoma of the endometrium; however, uterine sarcomas, including malignant mixed mullerian tumors (MMMT), generally associated with a higher FIGO stage (III/IV), also reported; uterine sarcoma at diagnosis usually associated with poor prognosis, and short survival; uterine sarcoma reported to occur more frequently among long-term users (≥2 years) of tamoxifen than non-users; promptly evaluate patient receiving or who has previously received therapy who reports abnormal vaginal bleeding; patients receiving or who have previously received tamoxifen should have annual gynecological examinations Therapy can cause fetal harm when administered to pregnant woman; there are postmarketing reports of vaginal bleeding, spontaneous abortions, birth defects, and fetal deaths in pregnant women taking tamoxifen; in primate model, administration of drug at doses 2 times maximum recommended human dose resulted in spontaneous abortion; advise pregnant women of potential risks to a fetus, including potential long-term risk of a DES-like syndrome; advise females of reproductive potential to use effective non-hormonal contraception during treatment with tamoxifen and for 9 months following the last dose Fetal harm may occur when administered to a pregnant woman There are postmarketing reports of vaginal bleeding, spontaneous abortions, birth defects, and fetal deaths in pregnant women taking tamoxifen In a primate model, administration of tamoxifen at doses 2 times the maximum recommended human dose resulted in spontaneous abortion Advise pregnant women of potential risks to a fetus, including potential long term risk of a DES-like syndrome Prior to initiating treatment, a negative pregnancy test should be confirmed Tamoxifen reported to inhibit lactation Two placebo-controlled studies in over 150 women have shown that tamoxifen significantly inhibits early postpartum milk production; both studies tamoxifen was administered within 24 hr of delivery for between 5 and 18 days; effect of tamoxifen on established milk production is not known There are no data that address whether tamoxifen is excreted into human milk; direct neonatal exposure of tamoxifen to mice and rats (not via breast milk) produced 1) reproductive tract lesions in female rodents (similar to those seen in humans after intrauterine exposure to diethylstilbestrol) and 2) functional defects of the reproductive tract in male rodents such as testicular atrophy and arrest of spermatogenesis Unknown if tamoxifen is excreted in human milk Because of potential for serious adverse reactions in nursing infants from tamoxifen, women taking tamoxifen should not breast feed Selective estrogen receptor modulator: nonsteroid with potent antiestrogenic effects in breast (but may be estrogen agonist in uterus); has cytostatic effect rather than cytocidal effects (cells accumulate in Go and G1 phase of the cell cycle) Half-Life: 7-14 hr Peak Plasma Time: 3-6 hr Protein binding: 99% Peak Plasma Concentration: 40 ng/m L Metabolism: by hepatic P450 enzyme CYP2C9, CYP2D6, CYP3A4 Metabolites: N-desmethyl tamoxifen, endoxifen Excretion: Feces (65%), urine (9%) Metabolized via CYP2D6 into endoxifen (4-OH-N-desmethyl-tamoxifen), its primary active metabolite Lowered CYP2D6 activity or concomitant CYP2D6 inhibitors may reduce tamoxifen efficacy Poor CYP2D6 metabolizers are defined as those with *4/*4 alleles On October 18, 2006, the Pharmaceutical Science Clinical Pharmacology Subcommittee of the FDA recommended including information on CYP2D6 genotypes and their potential effect on patient outcomes in the label for tamoxifen, but they did not come to consensus on whether testing should be recommended or considered optional Subsequent to that recommendation, branded tamoxifen (Nolvadex) was discontinued and no further guidance was given by FDA on whether to amend the label for generic tamoxifen Recent data presented at the 2010 San Antonio Breast Cancer Symposium found the CYP2D6 allele status had no effect on any outcomes, including disease recurrence, distant recurrence, and overall survival Further research will help elucidate the potential effect of strong CYP2D6 inhibitors, such as SSRIs, on tamoxifen metabolism, but there is no evidence to suggest that the use of such medications should influence the use of tamoxifen Therefore, based on the data available to date, routine testing for CYP2D6 variants is not recommended CYP2C19 heterozygous *2 carriership may be a predictive factor for patients with breast cancer using tamoxifen; this factor was associated with a longer survival among tamoxifen users in a recent study (Pharmacogenomics. 2010;11[10]:1367-75) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. The Truth About Tamoxifen Part 1 of 2 - The Truth About Cancer propranolol panic attacks Tamoxifen - Chemotherapy Drugs - Chemocare Tamoxifen - Oral - My Health Alberta - Government of Alberta
     
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