Clomipramine capsules are indicated for the treatment of: - the symptoms of depressive illness especially where sedation is required - obsessional and phobic states - adjunctive treatment of cataplexy associated with narcolepsy. In children and adolescents, there is not sufficient evidence of safety and efficacy of clomipramine in the treatment of depressive states, phobias and cataplexy associated with narcolepsy. The use of clomipramine in children and adolescents (0-17 years of age) in these indications is therefore not recommended (see section 4.4). Before initiating treatment with clomipramine, hypokalaemia should be treated (see section 4.4). After a response has been obtained, maintenance therapy should be continued at the optimum dose to avoid relapse. Patients with a history of recurrence require maintenance treatment for a longer duration. 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Clonidine has several off-label uses including the management of hypertensive crises, menopausal flushing (hot flashes), Tourette’s syndrome, attention deficit hyperactivity disorder (ADHD), opioid and alcohol withdrawal, smoking cessation, and migraine headache. In particular, it could be an issue for people who are prescribed the medication as a part of an opioid addiction treatment program. According to a study published in 10 out of 15 people who had sought treatment for opioid dependence acknowledged they had abused clonidine to decrease the amount of heroin needed to achieve the high they wanted and to prolong its duration. Though infrequently abused on its own, clonidine may be misused in conjunction with other intoxicating substances and may contribute to the development of compulsive patterns of drug use and addiction. It is possible to overdose on clonidine, and its misuse makes such an occurrence all the more likely. 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