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O 0 Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug-induced edema or edema secondary to heart failure Adults: Initially, 250 to 375 mg P. Paresthesias, GI disturbances, and lethargy are common. As your body adjusts to the medicine during treatment these side effects may go away. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. A heterocyclic sulphonamide used to manage respiratory acidosis by inhibiting renal carbonic anhydrase, which increases renal excretion of Na , K , and bicarbonate, and reduces ammonia excretion. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. 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Lopressor (metoprolol)." Novartis Pharmaceuticals, East Hanover, NJ. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. Effect Reduced serum p H; increased urine p H Dazamide®, Diamox® Therapeutics A heterocyclic sulfonamide used to manage respiratory acidosis by inhibiting renal carbonic anhydrase, which ↑ renal excretion of Na , K , and bicarbonate, and ↓ ammonia excretion; acetazolamide is also used to ↓ fluid retention in CHF, control 2º glaucoma and preoperatively in acute angle-closure glaucoma, epilepsy Effect ↓ Serum p H; ↑ urine p H Therapeutic range 10–15 µg/m L Toxic range ≥ 20 µg/m L A drug that inhibits the enzyme carbonic anhydrase in the kidney tubules, thus acting as a diuretic. 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