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It is active against many causative agents of the infection: gram-positive and gram-negative microorganisms. The presence of Clavulanic acid in Augmentin protects Amoxicillin against the destructive action of beta-lactamase and increases the antibacterial activity of this medication. As most penicillins, Amoxicillin is destroyed by beta-lactamase which has high resistance to the action of this medication. Augmentin actively inhibits the development of gram-positive aerobe and anaerobe, gram-negative aerobic and anaerobic microorganisms, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia spp, and many causative agents of the infection. In case of the monotherapy of the bacterial diseases, Amoxicillin is effective only if a causative agent of the infection is well known. The spectrum of the pharmacological activity of Augmentin is conditioned by two active ingredients but the mechanism of the action is mainly conditioned by the bactericidal effect of Amoxicillin. Augmentin destroys the cellular walls of bacteria and neutralizes the possibility pf their development and growth. The pharmacological action becomes quickly within several hours after the use of the pills. If you have ever been prescribed antibiotics for a bacterial infection, you have probably been given amoxicillin or Augmentin (amoxicillin clavulanate) at one time or another. If your child has ever needed antibiotics, both may have been prescribed. Amoxicillin is often the first antibiotic prescribed for common infections like ear infections and strep throat. It is typically used in young children because it is effective against many common childhood bacterial infections and doesn't have many severe side effects. By adding a beta-lactamase blocker to amoxicillin, Augmentin is able to overcome resistance to harder-to-treat bacteria, broadening the spectrum of infections it can treat. It is for this reason that Augmentin is referred to as a broad-spectrum antibiotic. 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