Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine protocol for travel Plaquenil side effects gum sores Hydroxychloroquine screening test Plaquenil is commonly used in rheumatoid arthritis, but was originally developed as an antimalarial medication. A number of immunodeficient conditions may be treated with Plaquenil, including Sjögren’s syndrome, a number of autoimmune diseases such as lupus and Coxiella burnetii-related heart infections. 4-6 Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Retinal changes with plaquenil Multimodal Imaging in Plaquenil Toxicity, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine lc3-iiHydroxychloroquine 200 mg does it have steroids in itChloroquine antidoteHow does the body metabolize plaquenilWhat is the half life of plaquenil Discontinued and the patient closely observed for possible progression of the abnormality. Retinal changes and visual disturbances may progress even after cessation of the therapy. See ADVERSE REACTIONS section Suicidal behavior has been reported in very rare cases in patients treated with hydroxychloroquine. PLAQUENIL HYDROXYCHLOROQUINE SULFATE, USP WARNING.. Conditions Plaquenil-related Eye Problems Eugene Eye Care. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. Evaluation of the retina can provide information regarding the presence and severity of many systemic diseases. Although many retinal findings are nonspecific, early recognition of these signs can help prevent ophthalmologic complications and vision loss. This ophthalmoscopic photograph shows a normal retina of the right eye.