Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

Discussion in 'Northwest Pharmaceuticals Canada' started by Sovsem, 28-Feb-2020.

  1. Nick325i User

    Chloroquine: mechanism of drug action and resistance in plasmodium falciparum


    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    Oct 04, 2002 Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a. During the past year, confirmed chloroquine-resistant infections have been described from specific areas in Zambia 3 and Sudan 4; previously, Kenya, Tanzania, Uganda, Madagascar, and the Comoros Islands were acknowledged to have transmission of chloroquine-resistant P. falciparum. In the pharmacological features of the chloroquine resistance in P. falciparun, namely the proposed efflux mechanism and the reversal of resistance by verapamil, desipramine and related compounds led to the proposal that a similar mechanism for drug resistance was operating in P. falciparum.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

    Plasmodium Chloroquine Resistance and the Search for a., Update Chloroquine-Resistant Plasmodium falciparum -- Africa

  2. Chloroquine ciprofloxacin
  3. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain.

    • Chloroquine - Prescription Drug Information..
    • MECHANISMS OF DRUG RESISTANCE IN PLASMODIUM FALCIPARUM.io=.
    • Chloroquine - Wikipedia.

    Drug transport is believed to be of crucial importance for understanding the mechanisms of chloroquine resistance, as it is clear that less chloroquine accumulates in chloroquine-resistant parasites than in chloroquine-sensitive parasites. It was originally thought that this lack of accumulation was the result of an efflux mechanism, and a P-glycoprotein was implicated as the pump responsible for the efflux. We believe that our results, besides shedding light on the mechanism of chloroquine resistance in P. falciparum, have implications for the development of novel therapies against resistant malaria strains and demonstrate the usefulness of an approach combining systems biology strategies with structural bioinformatics and experimental data. Oct 15, 1996 Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine.

     
  4. andreSam Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Drug Safety in Pregnant & Nursing Women. Vaccination recommendations for adult patients with rheumatic. What are the side effects of using hydroxychloroquine.
     
  5. Flamenko User

    Chloroquine has shown apparent efficacy in treatment of Covid. Poland has formally registered Chloroquine as a drug for COVID-19 and will treat all patients with it. Chloroquine phosphate is a generic antimalarial drug derived from quinolone, in 10 trials for Covid-19 in China, including one in combination with Kaletra, as chloroquine phosphate is believed to have broad-spectrum antiviral activities.

    Volume of distribution - Wikipedia
     
  6. cepik New Member

    Protecting your eyesight when taking Plaquenil Lupus. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications.

    Hydroxychloroquine Side Effects Common, Severe, Long Term.