Chloroquine exocytosis

Discussion in 'Hydroxychloroquine Sulfate' started by Reigan, 16-Mar-2020.

  1. notfidel Moderator

    Chloroquine exocytosis

    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Mar 08, 2011 Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively. Dilation is an indicator of lysosomal dysfunction. Of insertion into the plasma membrane by exocytosis and removal therefrom by endocytosis 6, we were prompted to look for a general effect of insulin upon endocytosis and exocytosis. The 3T3-Ll adipocyte in culture, a cell that ex- hibits insulin-stimulated hexose transport 7, €9, was chosen Treatment with the weak base chloroquine, which helps phagosome neutralization, significantly decreased the rate of nonlytic exocytosis. Since ammonium chloride, another weak base, plays an insignificant role in nonlytic exocytosis, we hypothesized that chloroquine may regulate nonlytic exocytosis via a phagosome-independent pathway.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine exocytosis

    Chloroquine Indications, Side Effects, Warnings -, THE OF Vol. No. of March hy The of in USA. Insulin Stimulates.

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  4. Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells. In Oncotarget. 2018 ; Vol. 9, No. 6. pp. 6883-6896.

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    Chloroquine, which is known to be concentrated in intracellular acid vesicles, stimulates the release of porphyrins from yeast. Experiments with normal baker's yeast Saccharomyces cerevisiae and the sec-1 mutant, with suppressed exocytosis, showed that the release of porphyrins was stimulated more in normal yeast than it was in the mutant. It is suggested that chloroquine stimulates the. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine is known to be a non-specific antiviral agent, but its effect on the Zika virus replication has not been evaluated yet. This is the first report of inhibitory effects of chloroquine on ZIKV replication, which, given the ongoing epidemics, may become interesting both for the scientific knowledge of the virus and for the clinical.

  5. bogdan_2005 Guest

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  6. moto25 New Member

    PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Hydroxychloroquine sulfate sulfate base, and are for oral PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION PLAQUENIL h. ydroxychloroquine sulfate is a. white or practically white, crystalline. powder freely. soluble in water; practically insoluble in alcohol, chloroform, and in ether. The. chemical. name for

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  7. sdiavlo XenForo Moderator

    Hydroxychloroquine Plaquenil Toxicity and Recommendations. Figure 3 Spectral domain optical coherence tomography demonstrates loss of the IS/OS junction and thinning of the outer retina in the parafoveal region arrows, with preservation of these structures in the fovea of both the right A and left B eyes. click on image for higher resolution

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