One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil p450 enzymes Hydroxychloroquine gingival hyperplasia Chloroquine lentivirus production Plaquenil can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis or HIV/AIDS; antidepressants or antipsychotic medicines; birth. Accidental exposure may cause death. If a child takes Plaquenil hydroxychloroquine by accident, get medical help right away. Use with care in children. Talk with the doctor. If you are 65 or older, use Plaquenil hydroxychloroquine with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or. Cushing's syndrome is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years, also take medication Methotrexate, and have Inflammation. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil cause cushing's Cushing syndrome - Symptoms and causes - Mayo Clinic, Plaquenil Indications, Side Effects, Warnings - Is plaquenil quinineHydroxychloroquine and lansoprazoleDoes plaquenil cause dry eyesDoes plaquenil cause liver damage Dec 15, 2017 7 health conditions that can cause hyperpigmentation. The abnormal amount of cortisol in the human body causes a condition known as the Cushing’s syndrome. Health conditions that can cause hyperpigmentation.. Will you have Cushing's syndrome with Plaquenil - eHealthMe. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. It would be unlikely IMO that the Plaquenil is the cause, since there is tapering necessary when stopping it and no documented 'withdrawal' syndrome associated with it. If you have taken it for a long time, it is probably not even out of your system yet, since Plaquenil has a half-life of 30-60 DAYS not hours. This reaction, called vasodilation, causes your skin to flush, a symptom most obvious on your face due to a variety of factors. He theorizes that it developed as a way to fend off a possible retaliatory response from another. The Mayo Clinic includes flushing as a major symptom of Cushing’s syndrome. Jun 01, 2017 Treatment for leukopenia depends on which type of white blood cell is low and what’s causing it. You may need other treatments to take care of any infections that develop from not having enough.