Sar of chloroquine slideshare

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by manishma, 24-Feb-2020.

  1. mircity User

    Sar of chloroquine slideshare


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch. Dec 09, 2012 Acute attack of chloroquine sensitive malaria• Tab. Chloroquine phosphate 250 mg – Contains 150 mg of base – Give 4 tablets stat, 2 tablets after 8 hours and, 1 tablet BD for 2 days• Patients who cannot take orally – 3.5 mg/kg IM every 6 hrs for 3 days• Tab primaquine 15 mg OD for 14 days in Plasmodium vivax, ovale• Primaqine 45 mg single dose for falciparum after chloroquine gametocidal Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Sar of chloroquine slideshare

    SAR and Pharmacophore Based Designing of Some Antimalarial., Antimalarial drugs -

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  5. Synthesis, Structure-Activity Relationship, & Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds Steven J. Burgess, † ‡ Jane X. Kelly, † Shawheen Shomloo, † ‡ Sergio Wittlin, § £ Reto Brun, § £ Katherine Liebmann, † and David H. Peyton * † ‡

    • Synthesis, Structure-Activity Relationship, & Mode-of-Action..
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    Feb 20, 2017 Chloroquine inhibits polymerization of heme and accumulation of heme. • Chloroquine binds to heme or fp to form what is known as the fp-chloroquine complex, this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic compound results in cell lysis and ultimately parasite cell autodigestion. 13. Chloroquine combined with primaquine is the treatment of choice for Chloroquine -sensitive infections. In mild-to-moderate G6PD deficiency, primaquine 0.75mg base/kg body weight given once a week for 8 weeks. Feb 12, 2016 Medicinal chemistry of Antiamoebic agents 1. Antiamoebic agents Mr. Ganesh AGCOP,satara 1 2. AMEBIASIS Amebiasis also called amebic dysentry is an infection of intestinal tract caused by Entamoeba histolytica. The disease can be acute or chronic, with the patients showing varying degrees of illness, from no symptoms to mild diarrhea to fulminating dysentery Dysentery in which the symptoms

     
  6. Neek Moderator

    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Chloroquine Mechanism of drug action and resistance in. Chloroquine - FDA prescribing information, side effects and uses How to Find Atomic Number 10 Steps with Pictures - wikiHow
     
  7. mastah Guest

    Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol. Plaquenil - Get up-to-date information on Plaquenil side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Plaquenil

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.