Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine vs malarone Hydroxychloroquine and retinal deposit Chloroquine resistant p falciparum Hearing problems, such as ringing or ticking in the ears, or hearing changes Plaquenil may have toxic effects on your inner ear Loss of balance, coordination, room spinning, or other vertigo. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Note that chloroquine is not used frequently in the United States and has been replaced by the use of hydroxychloroquine because the latter has fewer side effects. The Plaquenil Problem “Plaquenil toxicity is very distinctive,” said Michael F. Marmor, MD, professor of ophthalmology at Stanford University. Dr. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine ears Hydroxychloroquine MedlinePlus Drug Information, Hydroxychloroquine Plaquenil Toxicity and Recommendations. Chloroquine cancer treatment Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine Uses, Dosage & Side Effects -. Rx Side Effects New Plaquenil Guidelines and More - American.. ATIENT NFORMATION ON HYDROXYCHLOROQUINE. Continuing ringing or buzzing or other unexplained noise in the ears feeling of constant movement of self or surroundings irritability nausea nervousness nightmares sensation of spinning shakiness and unsteady walk uncontrolled eye movements unsteadiness, trembling, or other problems with muscle control or coordination vomiting I mentioned ringing in my ears to my rheumy a few months back. He had me go to an ENT to rule out Meniere's. They told me that plaquenil can cause it, but he did not think that it was that. So, anyway, after my appt. they determined that I have severe high frequency hearing loss and that is what is causing the ringing in my ears. The man had history of rheumatoid arthritis diagnosed from 3 months ago and was administered hydroxychloroquine 200 mg and prednisolone 5 mg twice daily. Audiometry test showed moderate to severe neuronal hearing loss and reduced speech recognition in both ears of the patient.