He had a history of rheumatoid arthritis, and had been treated with hydroxychloroquine for the last 8 years. Echocardiography revealed a left ventricular ejection fraction of 25%, with diffuse hypokinesis. Plaquenil to treat ankylosing spondylitis Prozac and plaquenil Is it safe to take hydroxychloroquine while pregnant We present a case of twin sisters who both suffered from systemic lupus erythematosus SLE and HCQ-induced cardiomyopathy presenting with decompensated heart failure HF, suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy. ATLANTA – Hydroxychloroquine Plaquenil 400 mg/day starting by pregnancy week 10 reduces recurrence of congenital heart block in infants born to women with anti-Ro antibodies, according to an open-label, prospective study presented at the annual meeting of the American College of Rheumatology. Discussion. Echocardiographic findings of HCQ cardiomyopathy are variable, ranging from increased ventricular wall thickness with or without dilatation and systolic or diastolic dysfunction and can mimic other causes of myocardial dysfunction in SLE patients such as myocarditis, amyloidosis, ischemic heart disease, other toxic drugs eg, amiodarone, and rarely, Fabry disease or other storage. The differential diagnosis for new onset non-ischemic cardiomyopathy in this patient included inflammatory cardiomyopathy, viral myocarditis, sarcoidosis, amyloidosis, hemochromatosis, Fabry's disease and HCQ toxicity. Coronary angiography demonstrated non-obstructive coronary disease. Treatment was initiated with guideline directed medical therapy, and patient clinically improved. Plaquenil and heart issues How lupus affects the heart and circulation Lupus Foundation of America, Hydroxychloroquine prevents congenital heart block. Chloroquine for malaria prophylaxis dosingShow me a picture of hydroxychloroquineHydroxychloroquine azithromycinHydroxychloroquine effects on folliculitis decalvansPlaquenil myositis Sep 13, 2017 We present a case of twin sisters who both suffered from systemic lupus erythematosus SLE and HCQ-induced cardiomyopathy presenting with decompensated heart failure HF, suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy. Hydroxychloroquine-induced cardiomyopathy and heart failure.. Hydroxychloroquine-Induced Cardiomyopathy Circulation Heart Failure. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine HCQ-induced cardiomyopathy is one of the rare but severe complications following prolonged HCQ use. However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case. HYDROXYCHLOROQUINE PLAQUENIL CARDIOTOXICITY AN UNCOMMON COMPLICATION OF A COMMON MEDICATION. Your Name has forwarded a page to you from JACC Journal of the American College of Cardiology. Your Name thought you would like to see this page from the JACC Journal of the American College of Cardiology web site. Plaquenil can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis or HIV/AIDS; antidepressants or antipsychotic medicines; birth.