Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Return of chloroquine antimalarial efficacy in malawi Plaquenil a steroid Serious Side Effects of Plaquenil If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. May 07, 2012 Saturday was a week since I stopped taking Plaquenil, aka Hydroxychloroquine, per my doctor's instructions, and I think I am going through some form of withdrawal. I took the drug as a treatment for sarcoidosis and one of the side effects is a reduction in white blood cells, which is what has happened to me. Plaquenil side effects. Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How long do plaquenil side effects last Plaquenil - how long for side effects to subside?, Plaquenil Withdrawal – Life As An Anomaly Rash with hydroxychloroquine What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. A lower dose may stop them. Do not lower the dose on. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Uses, Dosage & Side Effects -. Plaqunil rash -. If side effects do occur, they are usually minor and last only for a short period of time. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish. I still believe this to be true, but I am convinced now that plaquenil must have multiple modes of action, one being long term effects, and one being something happening in the short term. There is no way what I experienced over the last 4 days was due to placebo affect. By last night, I was so achy, tired, trouble breathing still, etc. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.