Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Neuropathy caused by plaquenil Plaquenil lupus nephritis High-risk patients would include those who have taken high doses of Plaquenil for years i.e. 1000 g. for over 7 years. are 60 years or older. are obese. have significant liver or kidney disease. have pre-existing retinal, macular disease, or cataracts. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Newer techniques for evaluation of retinal disease have been developed and these techniques can detect retinal toxicity earlier. Typical starting dose is 800 mg. This is followed by 400 mg three times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). How often do you take plaquenil How long did Plaquenil/Hydroxychloroquine take? DailyStrength, My Take on New Ocular Screening Guidelines for Plaquenil RheumNow. Plaquenil drinking alcoholPlaquenil info Research has shown that your risk of developing retinopathy is higher the longer you are taking Plaquenil. In fact, the incidence of retinal toxicity rises sharply in people that have taken it between 5 and 7 years. As a result, baseline testing should occur within the first year of taking the drug and then annually at the five-year mark. Plaquenil Side Effects on Your Eyes and Vision. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Plaquenil Indications, Side Effects, Warnings -. Do I need a prescription for hydroxychloroquine Plaquenil? What are the side effects of hydroxychloroquine Plaquenil? What is the dosage for hydroxychloroquine Plaquenil? Which drugs or supplements interact with hydroxychloroquine Plaquenil? Is hydroxychloroquine Plaquenil safe to take if I'm pregnant or breastfeeding? Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food. New Plaquenil dosing guidelines increase safety. 135 lbs. or more, any height - up to 400 mg Plaquenil daily. 102 lbs. to 134 lbs. - up to 300 mg Plaquenil daily. 101 lbs or less - up to 200 mg Plaquenil daily.