The fever is usually above 39 °C (102 °F) and sometimes reaching 40 °C (104 °F) and may be biphasic—lasting several days, breaking, and then returning. Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase. Mental side effects of plaquenil Taking two plaquenil instead of 1.5 The infection is of acute onset and variable clinical features are common findings 10,52,80. The symptoms develop after an incubation period of 4 to 7 days range 1-12 days. In most of the cases the disease is self limiting and the symptoms disappears within 5 to 7 days even without treatment. Jan 23, 2017 Several clinical trials still ongoing have attempted to establish the use chloroquine analogs in the prevention or treatment of several viral infections, including HIV, hepatitis, rabies, Chikungunya, Ebola virus disease, influenza A and B, and dengue viral infections Table 2. May 28, 2016 In a first clinical trial improvement of symptoms in the chronic phase of CHIKV infection were reported following chloroquine treatment 7, whereas another study failed to prove the efficacy of chloroquine as a treatment for the acute phase of CHIKV infection 8. However, headache, insomnia and an extreme degree of exhaustion remain, usually about five to seven days. When Ig M, an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish. On chikungunya acute infection and chloroquine treatment Symptoms, Diagnosis, & Treatment Chikungunya virus CDC, Targeting endosomal acidification by chloroquine analogs as a. Chloroquine mexico Chikungunya virus infection CHIKV is caused by a mosquito-borne alphavirus. CHIKV causes high fever and painful rheumatic disorders that may persist for years. Because little is known about interventions for treating CHIKV-related illness, we conducted a systematic review. Interventions for treating patients with chikungunya virus.. Antiviral Strategies Against Chikungunya Virus SpringerLink. Of chloroquine and COVID-19 - ScienceDirect. The vector. In Asia and the Indian Ocean region, Chikungunya fever is transmitted by the bite of mosquitoes of the genus Aedes which also transmit the dengue virus. Aedes aegypti is considered to be the principal vector and A. albopictus Asian Tiger mosquito has also recently emerged as an important vector. Chikungunya virus infection may resemble other illnesses such as dengue fever, Zika virus, malaria, mononucleosis, strep, and others, and it is important to rule out other causes for symptoms and signs. There is no specific medical treatment for chikungunya virus infection. Treatment is generally home remedies such as rest, fluids, and over-the-counter pain and fever medicines aimed at relief of symptoms and signs. These chronic signs of chikungunya are disabling and merit further attention, because there is currently no recommended treatment for chikungunya based on clinical trials 10 111213. Treatment instead depends on the response of the patient, ranging from non-steroidal anti-inflammatory drugs.