Please review the following URL and make sure that it is spelled correctly. Requested URL: /drugsatfda_docs/label/2017/009768s... Quinoric or plaquenil Chloroquine and immune complement activation Plaquenil induced bruising on shins Most cases of chloroquine retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 21 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 22 One study showed a 19% incidence of chloroquine retinopathy in. We present a case of neuropathy and myopathy in a woman treated chronically with hydroxychloroquine and recently added colchicine. Both agents were felt to have a role in her progressive decline, with hydroxychloroquine likely inducing a mild myopathy over the previous 12 months. Chloroquine is an antimalarial agent also used as standard treatment for a variety of rheumatologic and dermatologic disorders. 1,2 Myopathy and, to a lesser extent, neuropathy are well-documented complications of therapy with chloroquine and other antimalarial agents. 1,3 Chloroquine typically produces a vacuolar myopathy 1,2 characterized by progressive proximal weakness that resolves. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Chloroquine neuropathy Plaquenil causes and treats neuropathy? - NeuroTalk Support., Hydroxychloroquine and Colchicine Induced Myopathy The. Is plaquenilCan hydroxychloroquine cause hair loss Ago. Three of these drugs are now primarily used due to their safety profile. Chloroquine and hydroxychloroquine HCQ are 4-aminoquinoline derivatives. They are structurally similar, differing only by replacement UpToDate. Chloroquine myopathy and neuropathy with elevated CSF protein Neurology. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Effectiveness of Chloroquine and Hydroxychloroquine in Treating Selected Patients With Sarcoidosis With Neurological Involvement. Om P. Sharma, MD. Author Affiliations Article Information. From the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, Los Angeles. The latter is related to drug accumulation in melanin-rich tissues. 15,16 Prolonged treatment with chloroquine also can cause toxic myopathy, cardiopathy, and peripheral neuropathy and neuropsychiatric disturbances; all of these reactions improve if the drug is discontinued promptly. 17,18 Both chloroquine and hydroxychloroquine should be used. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.