Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Is it safe to take plaquenil and tramadol together Hydroxychloroquine gas Cornea verticillata plaquenil Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. Use of Plaquenil is contraindicated in patients with known hypersensitivity to 4-aminoquinoline compounds. Warnings Resistant strains of malaria Plaquenil is not effective against chloroquine-resistant strains of P. falciparum see CLINICAL PHARMACOLOGY – Microbiology. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil use with retinopathy Does Patient with Lupus Have Plaquenil Retinopathy?, Plaquenil - FDA prescribing information, side effects and uses Plaquenil for sjogren's reviewsHydroxychloroquine pulmonary fibrosis Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. Hydroxychloroquine Plaquenil Toxicity and.. Plaquenil Side Effects on Your Eyes and Vision. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy. Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Doctors generally recommend regular eye exams while on Plaquenil, so that early changes can be caught. Once abnormalities are discovered, toxicity has already occurred. While it may be reversible if caught early, hydroxychloroquine retinopathy is not always reversible.