One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine 250 mg tab Plaquenil and heart The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. Aug 14, 2017 Retinal Damage. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil retina damage Multimodal Imaging in Plaquenil Toxicity, Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine sulfate pricesPlaquenil neck painHow common is diarrhea with plaquenilPlaquenil and uctd Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; Common and Rare Side Effects for Plaquenil Oral. Plaquenil Uses, Dosage & Side Effects -. How to Succeed in Plaquenil Screenings. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Published September 15, 2014 Is Damage Still Occurring? Can Plaquenil macular toxicity continue to progress long after the patient stops taking the drug? By Diana L. Schechtman, OD and Paul M. Karpecki, OD Feb 19, 2020 PLAQUENIL is not effective against chloroquine-resistant strains of P. falciparum see CLINICAL PHARMACOLOGY - Microbiology. Ocular. Irreversible retinal damage has been observed in some patients who had received hydroxychloroquine sulfate.