Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Map of chloroquine resistant malaria Hydroxy chloroquine rheumatoid arthritis pregnancy Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria. HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. The lowest GoodRx price for the most common version of generic Plaquenil is around $20.41, 88% off the average retail price of $177.73. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil medication type Hydroxychloroquine MedlinePlus Drug Information, Hydroxychloroquine Oral Route Description and Brand Names. Why is p falciparum resistance to chloroquineChloroquine phosphate and leather coral Plaquenil is an anti-malarial drug and contains hydroxychloroquine sulfate. It is used for treatment of malaria, auto-immune diseases like lupus and arthritis. The exact mechanism of action of Plaquenil is not known. Its action against the malarial parasites is similar to the compound chlorquine phosphate. Canada Plaquenil - Canadian Drugs for Rheumatoid Arthritis.. What is Plaquenil? - GoodRx. Medications used to treat lupus Lupus Foundation of America. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Side effects, drug interactions, pregnancy safety information, and dosage information should be reviewed prior to taking this medication. It belongs to a class of medications known as disease-modifying antirheumatic drugs DMARDs. It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works. Antimalarials such as hydroxychloroquine HCQ, are among the oldest prescribed drugs still used in clinical practice. Relatively inexpensive and well tolerated, these drugs have been recognized to be effective in autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythematosus SLE.