Chloroquine inhibits autophagy in mice

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  1. Nebullah9 Moderator

    Chloroquine inhibits autophagy in mice


    Phone: (215) 746-5515; Fax: (215) 746-5511; E-mail: [email protected] in: JCI | Pub Med | Google Scholar Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, San Francisco, California, USA. Thompson, Department of Cancer Biology, Abramson Family Cancer Research Institute, 421 Curie Boulevard, 450 BRB II/III, Philadelphia, Pennsylvania 19104, USA. Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1].

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    Aug 26, 2018 Chloroquine CQ, a known autophagy inhibitor, disrupts lysosomal function by increasing lysosomal pH, thereby causing acidification, which, in turn, inhibits autophagy. The lung cancer cells were pretreated with CQ to determine whether AZD9291 induced an autophagic flux. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. which might contribute to the fusion impairment. Strikingly, HCQ-treated mice. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the.

    This accumulation leads to inhibition of lysosomal enzymes that require an acidic p H, and prevents fusion of endosomes and lysosomes. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN- Production. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes.

    Chloroquine inhibits autophagy in mice

    JCI - Autophagy inhibition enhances therapy-induced apoptosis., Chloroquine inhibits autophagic flux by decreasing.

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  6. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious

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    Oral administration of chloroquine, which inhibits autophagy, did not suppress damage to microglia and pericytes, but greatly reduced neuronal vacuolation and eliminated neuronal cells with. These studies provide evidence that autophagy serves as a survival pathway in tumor cells treated with apoptosis activators and a rationale for the use of autophagy inhibitors such as chloroquine in combination with therapies designed to induce apoptosis in human cancers. On the other hand, the very effect of chloroquine to inhibit autophagy could also sensitize kidney cells to chemotherapy, leading to acute kidney injury. Consistent with this notion, chloroquine-treated mice 60 mg/kg, daily are more vulnerable to kidney injury from ischemic–reperfusion injury than vehicle-treated mcie. This study may indicate possible additional effect of chloroquine in chemotherapy-induced kidney injury.

     
  7. SergeyBB Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil - FDA prescribing information, side effects and uses Plaquenil Hydroxychloroquine - Side Effects, Dosage. Will you have Heart failure with Plaquenil - eHealthMe
     
  8. warrior User

    Hydroxychloroquine sulfate definition of hydroxychloroquine. Definition of hydroxychloroquine sulfate in the Medical Dictionary by The Free Dictionary

    Hydroxychloroquine sulfate ≥98% HPLC, powder Sigma-Aldrich
     
  9. Dance XenForo Moderator

    Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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