Your peripheral nerves send messages from your brain and spinal cord to the rest of your body. When those nerves are damaged, these messages are interrupted and affect how your body responds to pain, temperature, and other reflexes. Drug interaction zantac and chloroquine Hydroxychloroquine retinal toxicity oct Mefloquine or plaquenil But it could also the pain meds I am on "Tramadol". The dryness is the same. I am still tired and fall asleep at a moments notice. The brain fog hasn't changed. So that is not much help, the main thing the Plaquenil is supposed to do, as I understand, feel free to let me know if you know more it's trying to stop the progression of the disease. I do not know if you take plaquenil or not, and I cannot say for sure it is the plaquenil, but I believe the plaquenil has helped with my peripheral neuropathy. I do not even know if it is supposed to help with it or not, but in the last six months since starting it, I have noticed a big improvement in many of my bothersome symptoms of ss. If your main symptoms are neuropathy related, then stick with something that is KNOWN to help immune mediated SFN, like IVIG. Plaquenil is primarily used to help with some of the symptoms of Sjogren's.reduce fatigue, and joint pain. It is also thought it help slow progression but not well documented for this. A few things can cause this damage: The effects of peripheral neuropathy can develop suddenly or can spread slowly over time. It’s often a result of damage to the peripheral nerves. Can plaquenil help to relieve neuropathy pain Natural Treatments for Peripheral Neuropathy, Can Plaquenil cause Peripheral Neuropathy? Hydroxychloroquine genericChloroquine and brain cancerPlaquenil cross eyes You might want to click on the Drugs A to Z tab at the top of this page. You can find out lots of information on peripheral neuropathy. I read some of it and I had two bouts of pancreatitis and one of the comments was that Zalcitabine can cause severe peripheral neuropathy and can also cause pancreatitis. Can plaquinel cause neuropathy? -. Plaquenil causes and treats neuropathy? - NeuroTalk Support.. Top 5 Ways to Relieve Peripheral Neuropathy Foot Pain.. Wear soft, loose cotton socks and padded shoes. You can use a semicircular hoop, which is available in medical supply stores, to keep bedcovers off hot or sensitive feet. Exercise. Regular exercise, such as walking three times a week, can reduce neuropathy pain, improve muscle strength and help control blood sugar levels. Peripheral neuropathy is found among people who take Plaquenil, especially for people who are female, 60+ old also take medication Methotrexate, and have High blood pressure. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated. Did your muscle pain come before, after or with the neuropathy? Did the Plaquenil help with the muscle joint part of your problem? Where was your neuropathy and what are you taking now if anything? When I took the Plaquenil I had RA antibodies and it was muscle / joint related. Thanks for responding.