Chikungunya disease and chloroquine treatment

Discussion in 'Canada Pharmaceuticals Online' started by 2seo, 21-Feb-2020.

  1. Lizard Well-Known Member

    Chikungunya disease and chloroquine treatment


    Listing a study does not mean it has been evaluated by the U. Most of cases are expressed as a mild disease, with intense fever and arthralgias, with rare but serious complications (encephalitis, liver, cardiac or renal failures.) having required a hospitalization in an intensive care unit. A severe outbreak of Chikungunya fever has been reported at La Réunion Island (France) in 2005-2006. Chikungunya virus is an alphavirus transmitted to humans by the bite of infected mosquitoes, usually of the genus Aedes (Aedes albopictus in La Réunion).

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    In an open labeled pilot trial n=20 that was published 25 years ago, Brighton reported the efficacy of chloroquine phosphate 250 mg/day in the treatment of patients with chronic Chikungunya arthritis. Of the 10 patients who completed 20 weeks of therapy, Ritchie articular index and morning stiffness improved significantly. It is true that chloroquine displays antiviral and anti-inflammatory properties that, in our opinion, merit testing in the clinical management of some viral diseases. However, we reported no data on chikungunya, nor did we mention this disease in our articles in The Lancet Infectious Diseases. A clinical trial conducted during the chikungunya outbreak in 2006 in Réunion Island showed that oral chloroquine treatment did not improve the course of the acute disease De Lamballerie et al. 2008 and that chronic arthralgia on day 300 post-illness was more frequent in treated patients than in the control group Roques et al. 2018.

    Chikungunya was proven in 246 serious cases; 101 patients had comorbidities, and 27% of confirmed cases eventually died. 273 of such serious cases (immediately life threatening condition) have been reported among the cases, in patients aged over 10 days (59% were 65 age old).

    Chikungunya disease and chloroquine treatment

    Chloroquine Known as Effective Against Coronavirus Since 2005, On the use of chloroquine for chikungunya - The Lancet.

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  7. Chloroquine for the treatment of Viral infections Chloroquine was also studied in patients who got infected with the Chikungunya virus. The drug was effective in the non-human primate model but it enhanced chikungunya virus replication and delayed cellular and humoral responses.

    • Antimalarial Drug revives the hope to treat Coronavirus..
    • Of chloroquine and COVID-19 - ScienceDirect.
    • Chikungunya fever Treatment and prevention - UpToDate.

    In recent issues, the efficacy of chloroquine and the dosage that may be used in the treatment of acute chikungunya infections was discussed. We have conducted a double-blind placebo-controlled randomized trial on the French Reunion Island Indian Ocean, in which 27 patients received chloroquine and 27 patients received a placebo treatment. Chikungunya disease and chloroquine treatment. Ilenia Delogu. Unité des Virus Emergents, UMR190 Aix‐Marseille 2 University‐IRD‐EHESP, Marseille, France. Chikungunya Disease and Chloroquine Treatment. CHIKV is the aetiological agent of the mosquito-borne disease chikungunya fever, a debilitating arthritic disease that, during the past seven.

     
  8. Peter2008 Moderator

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  9. gorelict New Member

    Chloroquine - FDA prescribing information, side effects. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.

    Post-exposure Chloroquine Prophylaxis COVID19