Chloroquine use in sle

Discussion in 'Buy Chloroquine Online' started by Prokur, 15-Mar-2020.

  1. e_fire XenForo Moderator

    Chloroquine use in sle


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. 1 It is taken by mouth. Initial dose for the treatment of SLE, 400mg×2/day, is about the dose used in one of the studies above. Maintenance dose would keep the serum concentration constant. Assuming HCQ is effective, it would most definitely be protective in doses used in SLE patients. Chloroquine and hydroxychloroquine are drugs derived from the quinoline molecule. Both are used as antimalarial blood schizonticides, and hydroxychloroquine is also frequently used as an antirheumatic. Their mechanism of action is not entirely understood.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine use in sle

    Chloroquine Capsules - Antimalarial Treatment for Lupus., Hydroxychloroquine Plaquenil thread COVID19

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  7. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus.

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    The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy cornea verticillata and, more importantly, an irreversible sight-threatening maculopathy. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue Hydroxychloroquine HCQ, is a 4-aminoquinoline drug used widely in autoimmune disease, but has also been employed for the treatment of malaria,1 where it is reported as being half as toxic as the closely-related chloroquine CQ yet equally active against Plasmodium falciparum.2 In UK travel medicine, three drug regimens atovaquone–proguanil, mefloquine or doxycycline are currently recommended for use in sub-Saharan Africa and other areas with high transmission rates of CQ-resistant P.

     
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    Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. Mefloquine resistance in Plasmodium. - PubMed Central PMC Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Malaria & treatment Flashcards Quizlet
     
  9. raulet.nicu Guest

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.

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